27. Graves disease: Difference between revisions
(Created page with "'''Staining''': HE '''Organ''': Thyroid '''Description''': Normal thyroid follicles are replaced by two types of abnormal follicles: * Hypertrophic follicles * Follicles with resorption vacuoles The follicular cells of the hypertrophic follicles are hypertrophic (large). These follicles have no visible lumen or colloid substance. Due to the hyperactivity of the thyroid follicular cells these cells will quickly consume colloid. This leaves behind small “vacuoles...") |
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'''Staining''': HE | [[File:Graves disease - overview.png|thumb|Overview]]'''Staining''': HE | ||
'''Organ''': Thyroid | '''Organ''': Thyroid | ||
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Due to the hyperactivity of the thyroid follicular cells these cells will quickly consume colloid. This leaves behind small “vacuoles” that line the follicular cells. It looks like the follicular cells “take a bite” out of the colloid substance. | Due to the hyperactivity of the thyroid follicular cells these cells will quickly consume colloid. This leaves behind small “vacuoles” that line the follicular cells. It looks like the follicular cells “take a bite” out of the colloid substance. | ||
As Graves disease is an autoimmune disease, which by definition are chronic, lymphocytic infiltration is present as well. | As Graves disease is an autoimmune disease, which by definition are chronic, lymphocytic infiltration is present as well.[[File:Graves disease - resorption vacuoles.png|thumb|Resorption vacuoles]]'''Diagnosis''': Graves disease | ||
'''Diagnosis''': Graves disease | |||
'''Risk factors:''' | '''Risk factors:''' | ||
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Nothing special. | Nothing special. | ||
[[File:Graves disease - hypertrophic follicles.png|thumb|Hypertrophic follicles|left]] | |||
[[File:Graves disease - lymphocytic infiltrate.png|thumb|Lymphocytic infiltrate]] | |||
[[File:Graves disease - hypertrophic follicles.png | |||
[[File:Graves disease - lymphocytic infiltrate.png | |||
[[Category:Pathology 2 - Histopathology slides]] | [[Category:Pathology 2 - Histopathology slides]] | ||
Revision as of 14:14, 7 July 2024
Staining: HE
Organ: Thyroid
Description:
Normal thyroid follicles are replaced by two types of abnormal follicles:
- Hypertrophic follicles
- Follicles with resorption vacuoles
The follicular cells of the hypertrophic follicles are hypertrophic (large). These follicles have no visible lumen or colloid substance.
Due to the hyperactivity of the thyroid follicular cells these cells will quickly consume colloid. This leaves behind small “vacuoles” that line the follicular cells. It looks like the follicular cells “take a bite” out of the colloid substance.
As Graves disease is an autoimmune disease, which by definition are chronic, lymphocytic infiltration is present as well.
Diagnosis: Graves disease
Risk factors:
- Young females
Theory:
Nothing special.
