22. Glioblastoma: Difference between revisions
(Created page with "'''Staining''': HE '''Organ''': Brain '''Description''': There are four important characteristics in glioblastomas: * Severe atypia * Many mitotic figures * Pseudopalisading necrosis * Microvascular proliferation Microvascular proliferation is a phenomenon where the tumor contains small capillaries who are irregular and are comprised of atypical endothelial cells. Pseudopalisading necrosis is a phenomenon where the tumor contains areas of necrosis, and this necrosi...") |
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'''Staining''': HE | [[File:Glioblastoma - Overview.png|thumb|Overview|362x362px]]'''Staining''': HE | ||
'''Organ''': Brain | '''Organ''': Brain | ||
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Pseudopalisading necrosis is a phenomenon where the tumor contains areas of necrosis, and this necrosis is surrounded by hypercellular regions. | Pseudopalisading necrosis is a phenomenon where the tumor contains areas of necrosis, and this necrosis is surrounded by hypercellular regions. | ||
'''Diagnosis''': Glioblastoma | '''Diagnosis''': Glioblastoma[[File:Glioblastoma - pseudopalisading necrosis.png|thumb|Pseudopalisading necrosis. The hypercellular regions form a “fence” around the necrosis.|329x329px]]'''Risk factors:''' | ||
'''Risk factors:''' | |||
* Age 50 – 70 | * Age 50 – 70 | ||
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Glioblastoma is a grade IV astrocytic tumor that is defined histologically be the four characteristics described above. It must be differentiated from ''anaplastic astrocytoma'', a grade III astrocytic tumor. Anaplastic astrocytoma also shows severe atypia and many mitotic figures but no pseudopalisading necrosis or microvascular proliferation. | Glioblastoma is a grade IV astrocytic tumor that is defined histologically be the four characteristics described above. It must be differentiated from ''anaplastic astrocytoma'', a grade III astrocytic tumor. Anaplastic astrocytoma also shows severe atypia and many mitotic figures but no pseudopalisading necrosis or microvascular proliferation. | ||
[[File:Glioblastoma - atypia.png|thumb|Tumor cells show severe atypia and there are many mitotic figures present.|left|364x364px]] | |||
[[File:Glioblastoma - microvascular proliferation.png|thumb|Tumor on the left, showing microvascular proliferation. Normal brain parenchyme on the right for comparison.|346x346px]] | |||
[[File:Glioblastoma - atypia.png | |||
[[File:Glioblastoma - microvascular proliferation.png | |||
[[Category:Pathology 2 - Histopathology slides]] | [[Category:Pathology 2 - Histopathology slides]] | ||
Revision as of 14:06, 7 July 2024
Staining: HE
Organ: Brain
Description:
There are four important characteristics in glioblastomas:
- Severe atypia
- Many mitotic figures
- Pseudopalisading necrosis
- Microvascular proliferation
Microvascular proliferation is a phenomenon where the tumor contains small capillaries who are irregular and are comprised of atypical endothelial cells.
Pseudopalisading necrosis is a phenomenon where the tumor contains areas of necrosis, and this necrosis is surrounded by hypercellular regions.
Diagnosis: Glioblastoma
Risk factors:
- Age 50 – 70
Theory:
Glioblastoma is a grade IV astrocytic tumor that is defined histologically be the four characteristics described above. It must be differentiated from anaplastic astrocytoma, a grade III astrocytic tumor. Anaplastic astrocytoma also shows severe atypia and many mitotic figures but no pseudopalisading necrosis or microvascular proliferation.
