51. Lepidic adenocarcinoma: Difference between revisions
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[[File:Lepidic adenocarcinoma lung overview.png|thumb|Overview of the slide]]'''Staining''': HE | [[File:Lepidic adenocarcinoma lung overview.png|thumb|Overview of the slide]]'''Staining''': HE '''Organ''': Lung | ||
'''Description''': The slide has two zones. The lower zone shows healthy, unaffected lung parenchyme. The upper zone shows normal structure of the alveoli, however the insides of the alveoli are lined by tumor cells. | |||
'''Description''': | |||
The slide has two zones. The lower zone shows healthy, unaffected lung parenchyme. The upper zone shows normal structure of the alveoli, however the insides of the alveoli are lined by tumor cells. | |||
'''Diagnosis''': Lepidic adenocarcinoma | '''Diagnosis''': Lepidic adenocarcinoma | ||
Revision as of 12:59, 5 July 2024
Staining: HE Organ: Lung
Description: The slide has two zones. The lower zone shows healthy, unaffected lung parenchyme. The upper zone shows normal structure of the alveoli, however the insides of the alveoli are lined by tumor cells.
Diagnosis: Lepidic adenocarcinoma
Risk factors: Asian ethnicity, smoking Genetic mutations
Theory:
Five types of lung adenocarcinomas exist:
- Papillary type
- Acinar type
- Solid type
- Micropapillary type (worse prognosis)
- Lepidic type (best prognosis)
This histology slide shows a “lepidic” growth pattern, which is the pattern where the tumor cells line the alveolar walls instead of invading the interstitium. The alveolar structure is therefore maintained. It’s technically an adenocarcinoma in situ because it hasn’t passed the basement membrane yet. Like other lung adenocarcinoma it's associated with mutations in EGFR, KRAS, ALK, PDL-1.
