48. Silicosis: Difference between revisions

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[[File:Silicosis silicotic nodule.png|thumb|Close-up of a silicotic nodule|left]]
[[File:Silicosis silicotic nodule.png|thumb|Close-up of a silicotic nodule|left]]
[[File:Silicosis peripheral zone.png|thumb|From the peripheral zone]]
[[File:Silicosis peripheral zone.png|thumb|From the peripheral zone]]
[[File:Silicosis central zone.png|thumb|From the central zone. No cells, just scar tissue|left|284x284px]]
[[File:Silicosis central zone.png|thumb|From the central zone. No cells, just scar tissue|left|225x225px]]
[[Category:Pathology 1 - Histopathology slides]]
[[Category:Pathology 1 - Histopathology slides]]

Revision as of 12:49, 5 July 2024

Overview of the slide

Staining: HE

Organ: Lung

Description:

The lung parenchyme is normal, however some large nodules can be seen. These nodules have two zones, the peripheral zone and central zone. Anthracosis is also present. The peripheral zone contains macrophages and fibroblasts. The central zone contains scar tissue and no cells.

Diagnosis: Silicosis

Causes:

  • Silica dust inhalation

Theory:

The central zone contains no cells, so it can be mistaken for necrosis. Compare these silicotic nodules to the necrotic granulomas in miliary tuberculosis and don’t mix them!

Close-up of a silicotic nodule
From the peripheral zone
From the central zone. No cells, just scar tissue