15. Normal and hypertrophic cardiac muscle: Difference between revisions
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'''Theory''': The only differences that can be seen in hypertrophic myocardium compared to normal is the presence of fibrosis and the enlarged nuclei of the cells. It’s important to note that not only infarction can lead to fibrosis. Fibrosis can be present in hypertrophy as well. Lipofuscin can also be found in other tissues and diseases than hypertrophic myocardium (as you should know by now). It is therefore not characteristic for hypertrophy, but can be seen more commonly in hypertrophy.[[File:Hypertrophic myocardium - fibrosis.jpg|thumb|Fibrosis|left]] | '''Theory''': The only differences that can be seen in hypertrophic myocardium compared to normal is the presence of fibrosis and the enlarged nuclei of the cells. It’s important to note that not only infarction can lead to fibrosis. Fibrosis can be present in hypertrophy as well. Lipofuscin can also be found in other tissues and diseases than hypertrophic myocardium (as you should know by now). It is therefore not characteristic for hypertrophy, but can be seen more commonly in hypertrophy.[[File:Hypertrophic myocardium - fibrosis.jpg|thumb|Fibrosis|left]] | ||
[[File:Hypertrophic myocardium - enlarged nuclei.jpg|center|thumb|Enlarged nuclei and lipofuscin]] | [[File:Hypertrophic myocardium - enlarged nuclei.jpg|center|thumb|Enlarged nuclei and lipofuscin|274x274px]] | ||
[[File:Hypertrophic myocardium - comparison.jpg|center|thumb|Comparison between the normal (left) and hypertrophic myocardium (right) at the same (20x) magnification. ]] | [[File:Hypertrophic myocardium - comparison.jpg|center|thumb|Comparison between the normal (left) and hypertrophic myocardium (right) at the same (20x) magnification. ]] | ||
[[Category:Pathology 1 - Histopathology slides]] | [[Category:Pathology 1 - Histopathology slides]] | ||
Latest revision as of 11:21, 5 July 2024
Staining: HE
Organ: Heart
Description: We see two pieces of heart tissue. The piece in the upper right corner is from a healthy heart, while the piece in the lower left corner is from a diseased heart. Comparing the two pieces, we can see that the diseased heart tissue has lipofuscin in the cells, enlarged nuclei, and interstitial fibrosis (pale morphology that differs from the rest of the myocardium).
Diagnosis: Hypertrophic cardiac muscle
Theory: The only differences that can be seen in hypertrophic myocardium compared to normal is the presence of fibrosis and the enlarged nuclei of the cells. It’s important to note that not only infarction can lead to fibrosis. Fibrosis can be present in hypertrophy as well. Lipofuscin can also be found in other tissues and diseases than hypertrophic myocardium (as you should know by now). It is therefore not characteristic for hypertrophy, but can be seen more commonly in hypertrophy.
