Gastroesophageal reflux disease: Difference between revisions
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Gastroesophageal reflux disease (GERD) (or gastro-oesophageal reflux disease in British English, but that's abbreviated GORD) is a common disease where gastric contents reflux into the oesophagus, causing symptoms like heartburn, regurgitation, and possible severe complications. It’s caused by excessive relaxation of the lower oesophageal sphincter, and is therefore sort of the opposite disorder of achalasia. | '''Gastroesophageal reflux disease''' (GERD) (or '''gastro-oesophageal reflux disease''' in British English, but that's abbreviated GORD) is a common disease where gastric contents reflux into the oesophagus, causing symptoms like heartburn, regurgitation, and possible severe complications. It’s caused by excessive relaxation of the lower oesophageal sphincter, and is therefore sort of the opposite disorder of [[achalasia]]. | ||
== Etiology == | == Etiology == | ||
Risk factors include those which decrease the tone of the LES and/or increase the pressure inside the stomach: | Risk factors include those which decrease the tone of the LES and/or increase the pressure inside the stomach: | ||
* Smoking | * [[Smoking]] | ||
* Coffee consumption | * Coffee consumption | ||
* Alcohol consumption | * [[Alcohol]] consumption | ||
* Obesity | * [[Obesity]] | ||
* Pregnancy | * Pregnancy | ||
* Scleroderma | * [[Scleroderma]] | ||
* Sliding hiatal hernia | * Sliding [[hiatal hernia]] | ||
== Classification == | == Classification == | ||
| Line 19: | Line 19: | ||
* Complicated erosive reflux disease | * Complicated erosive reflux disease | ||
In NERD, which accounts for 60% of cases, the gastroesophageal mucosa is visibly normal. In ERD, erosions are present on the mucosa. Complicated ERD is characterised by the presence of complications like ulcers, stenosis, or Barrett oesophagus. | In NERD, which accounts for 60% of cases, the gastroesophageal mucosa is visibly normal. In ERD, erosions are present on the mucosa. Complicated ERD is characterised by the presence of complications like [[Oesophageal ulcer|ulcers]], [[Oesophageal stenosis|stenosis]], or [[Barrett oesophagus]]. | ||
== Clinical features == | == Clinical features == | ||
The typical symptoms of GERD are heartburn and regurgitation. Atypical symptoms may occur if the regurgitation reaches the larynx, bronchi, or teeth, causing symptoms like hoarseness and coughing. | The typical symptoms of GERD are heartburn and regurgitation. Atypical symptoms may occur if the regurgitation reaches the larynx, bronchi, or teeth, causing symptoms like hoarseness and coughing. | ||
In complicated GERD the patient may have strictures or oesophagitis, which may cause dysphagia or odynophagia, or | In complicated GERD the patient may have strictures or oesophagitis, which may cause dysphagia or odynophagia, or constant pain. | ||
== Diagnosis and evaluation == | == Diagnosis and evaluation == | ||
In most cases, patients don’t need to undergo procedures for the precise diagnosis. If a patient with typical symptoms presents without being at risk of complications, the patient can undergo a so-called ''PPI test''. The patient is prescribed a PPI for 4 weeks, and if the symptoms improve, then the diagnosis of GERD is likely. | In most cases, patients don’t need to undergo procedures for the precise diagnosis. If a patient with typical symptoms presents without being at risk of complications, the patient can undergo a so-called ''[[Proton pump inhibitor|PPI]] test''. The patient is prescribed a PPI for 4 weeks, and if the symptoms improve, then the diagnosis of GERD is likely. | ||
In cases where the diagnosis is uncertain, proper diagnostic modalities are necessary. There are many options: | In cases where the diagnosis is uncertain, proper diagnostic modalities are necessary. There are many options: | ||
* Upper endoscopy (first choice) | * [[Upper endoscopy]] (first choice) | ||
* Oesophageal manometry | * [[Oesophageal manometry]] | ||
* 24-hour oesophageal pH measurement | * 24-hour oesophageal pH measurement | ||
* Impedance measurement | * Impedance measurement | ||
* Bilitec | * [[Bilitec]] | ||
== Treatment == | == Treatment == | ||
Treatment involves lifestyle changes such as smoking cessation, weight loss, not eating before bedtime, elevating the head in the bed. | Treatment involves lifestyle changes such as smoking cessation, weight loss, not eating before bedtime, elevating the head in the bed. | ||
In most cases, medical therapy is necessary. The standard treatment is PPIs. Alternatives include H2 receptor antagonists, antacids, and surface agents like sucralfate. | In most cases, medical therapy is necessary. The standard treatment is [[PPI|PPIs]]. Alternatives include [[H2 receptor antagonist|H2 receptor antagonists]], [[Antacid|antacids]], and surface agents like [[sucralfate]]. | ||
For surgical treatment, refer to the corresponding surgery topic. | For surgical treatment, refer to the corresponding surgery topic. | ||
| Line 47: | Line 47: | ||
* Erosive reflux disease | * Erosive reflux disease | ||
* Barrett oesophagus, oesophageal carcinoma | * [[Barrett oesophagus]], [[Oesophageal cancer|oesophageal carcinoma]] | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
Revision as of 12:00, 27 October 2023
Gastroesophageal reflux disease (GERD) (or gastro-oesophageal reflux disease in British English, but that's abbreviated GORD) is a common disease where gastric contents reflux into the oesophagus, causing symptoms like heartburn, regurgitation, and possible severe complications. It’s caused by excessive relaxation of the lower oesophageal sphincter, and is therefore sort of the opposite disorder of achalasia.
Etiology
Risk factors include those which decrease the tone of the LES and/or increase the pressure inside the stomach:
- Smoking
- Coffee consumption
- Alcohol consumption
- Obesity
- Pregnancy
- Scleroderma
- Sliding hiatal hernia
Classification
We distinguish GERD into one of three types:
- Non-erosive reflux disease (NERD)
- Erosive reflux disease (ERD), also called erosive oesophagitis
- Complicated erosive reflux disease
In NERD, which accounts for 60% of cases, the gastroesophageal mucosa is visibly normal. In ERD, erosions are present on the mucosa. Complicated ERD is characterised by the presence of complications like ulcers, stenosis, or Barrett oesophagus.
Clinical features
The typical symptoms of GERD are heartburn and regurgitation. Atypical symptoms may occur if the regurgitation reaches the larynx, bronchi, or teeth, causing symptoms like hoarseness and coughing.
In complicated GERD the patient may have strictures or oesophagitis, which may cause dysphagia or odynophagia, or constant pain.
Diagnosis and evaluation
In most cases, patients don’t need to undergo procedures for the precise diagnosis. If a patient with typical symptoms presents without being at risk of complications, the patient can undergo a so-called PPI test. The patient is prescribed a PPI for 4 weeks, and if the symptoms improve, then the diagnosis of GERD is likely.
In cases where the diagnosis is uncertain, proper diagnostic modalities are necessary. There are many options:
- Upper endoscopy (first choice)
- Oesophageal manometry
- 24-hour oesophageal pH measurement
- Impedance measurement
- Bilitec
Treatment
Treatment involves lifestyle changes such as smoking cessation, weight loss, not eating before bedtime, elevating the head in the bed.
In most cases, medical therapy is necessary. The standard treatment is PPIs. Alternatives include H2 receptor antagonists, antacids, and surface agents like sucralfate.
For surgical treatment, refer to the corresponding surgery topic.
Complications
- Erosive reflux disease
- Barrett oesophagus, oesophageal carcinoma