49. Microcellular carcinoma of the lung: Difference between revisions

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(Created page with "'''Staining''': HE '''Organ''': Lung '''Description''': We can see some normal lung parenchyme that has been invaded by multiple foci. There is also a large tumor on the left of the slide. The cells of the tumor are very small, and the tumor forms no structure. Some areas show cell with nuclei that “mold” into each other. Many mitotic figures are visible. The chromatin of the tumor cells is granular, making it look like salt and pepper. '''Diagnosis''': Small...")
 
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'''Staining''': HE
[[File:Small cell lung cancer overview.png|thumb|Overview of the slide|238x238px]]'''Staining''': HE '''Organ''': Lung


'''Organ''': Lung
'''Description''': We can see some normal lung parenchyme that has been invaded by multiple foci. There is also a large tumor on the left of the slide.


'''Description''':
The cells of the tumor are very small, and the tumor forms no structure. Some areas show cell with nuclei that “mold” into each other. Many mitotic figures are visible.[[File:Small cell lung cancer tumour cells.png|thumb|Close-up. The cells don’t form any structures (glands, layers).|245x245px]]
 
We can see some normal lung parenchyme that has been invaded by multiple foci. There is also a large tumor on the left of the slide.
 
The cells of the tumor are very small, and the tumor forms no structure.
 
Some areas show cell with nuclei that “mold” into each other.
 
Many mitotic figures are visible.


The chromatin of the tumor cells is granular, making it look like salt and pepper.
The chromatin of the tumor cells is granular, making it look like salt and pepper.
Line 17: Line 9:
'''Diagnosis''': Small-cell lung carcinoma
'''Diagnosis''': Small-cell lung carcinoma


'''Causes''':
'''Risk factors''': Smoking
 
* Smoking
 
'''Theory''':
 
Small-cell lung originates from neuroendocrine cells in the lung. It gets its name from the fact that the tumor cells are really small. The cells also have very little cytoplasm. They’re pleomorphic and mitotic figures can also be seen.
 
Nuclear moulding is a morphological sign where the nuclei of two cells appear to be in contact. This signs occurs because the cells have so little cytoplasm that the whole cell is basically just the nucleus, making it look like the cells’ nuclei are in contact.
 
The fact that we have many small foci in addition to the large tumor is also characteristic for small-cell carcinoma.


Small-cell lung carcinoma has a much worse prognosis than non-small cell carcinoma (squamous and adenocarcinoma).
'''Theory''': Small-cell lung originates from neuroendocrine cells in the lung. It gets its name from the fact that the tumor cells are really small. The cells also have very little cytoplasm. They’re pleomorphic and mitotic figures can also be seen.


A small-cell carcinoma is a type III neuroendocrine tumor. The salt-n-pepper morphology is characteristic for neuroendocrine tumors.
Nuclear moulding is a morphological sign where the nuclei of two cells appear to be in contact. This signs occurs because the cells have so little cytoplasm that the whole cell is basically just the nucleus, making it look like the cells’ nuclei are in contact. The fact that we have many small foci in addition to the large tumor is also characteristic for small-cell carcinoma.[[File:Small cell lung cancer mitosis.png|thumb|This poor cell was in the middle of dividing when it died.|163x163px]]Small-cell lung carcinoma has a much worse prognosis than non-small cell carcinoma (squamous and adenocarcinoma).A small-cell carcinoma is a type III neuroendocrine tumor. The salt-n-pepper morphology is characteristic for neuroendocrine tumors.[[File:Small cell lung cancer nuclear moulding.png|thumb|Nuclear moulding. Note the small size of the tumor cells. Note also their pleomorphism.|236x236px|none]]
[[File:Small cell lung cancer overview.png|center|thumb|Overview of the slide]]
[[File:Small cell lung cancer tumour cells.png|center|thumb|Close-up of the tumor. Note that the cells don’t form any structures (glands, layers). They just exist next to each other.]]
[[File:Small cell lung cancer nuclear moulding.png|center|thumb|Nuclear moulding. Note the small size of the tumor cells. Note also their pleomorphism (anisochromasia, anisonucleosis, anisocytosis).]]
[[File:Small cell lung cancer mitosis.png|center|thumb|This poor cell was in the middle of dividing when it died.]]
[[Category:Pathology 1 - Histopathology slides]]
[[Category:Pathology 1 - Histopathology slides]]

Latest revision as of 14:09, 5 July 2024

Overview of the slide

Staining: HE Organ: Lung

Description: We can see some normal lung parenchyme that has been invaded by multiple foci. There is also a large tumor on the left of the slide.

The cells of the tumor are very small, and the tumor forms no structure. Some areas show cell with nuclei that “mold” into each other. Many mitotic figures are visible.

Close-up. The cells don’t form any structures (glands, layers).

The chromatin of the tumor cells is granular, making it look like salt and pepper.

Diagnosis: Small-cell lung carcinoma

Risk factors: Smoking

Theory: Small-cell lung originates from neuroendocrine cells in the lung. It gets its name from the fact that the tumor cells are really small. The cells also have very little cytoplasm. They’re pleomorphic and mitotic figures can also be seen.

Nuclear moulding is a morphological sign where the nuclei of two cells appear to be in contact. This signs occurs because the cells have so little cytoplasm that the whole cell is basically just the nucleus, making it look like the cells’ nuclei are in contact. The fact that we have many small foci in addition to the large tumor is also characteristic for small-cell carcinoma.

This poor cell was in the middle of dividing when it died.

Small-cell lung carcinoma has a much worse prognosis than non-small cell carcinoma (squamous and adenocarcinoma).A small-cell carcinoma is a type III neuroendocrine tumor. The salt-n-pepper morphology is characteristic for neuroendocrine tumors.

Nuclear moulding. Note the small size of the tumor cells. Note also their pleomorphism.