47. Bronchial asthma: Difference between revisions
(Created page with "'''Staining''': HE and PAS '''Organ''': Lung '''Description''': The lung parenchyme is normal. However, the bronchus shows 6 alterations: # A mucus plug in the lumen # Goblet cell hyperplasia in the respiratory lumen # Thickened basement membrane # Lymphocytes, eosinophils in the sub-epithelial layer # Smooth muscle hypertrophy and hyperplasia # Mucus gland hyperplasia Alteration 1, 2, 3 and 6 are PAS positive '''Diagnosis''': Bronchial asthma '''Etiology''': * H...") |
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'''Staining''': HE and PAS | [[File:Bronchial asthma overview.png|thumb|Overview of the slides|372x372px]]'''Staining''': HE and PAS | ||
'''Organ''': Lung | '''Organ''': Lung | ||
'''Description''': | '''Description''': [[File:Bronchial asthma mucus plug.png|thumb|Mucus plug and other characteristic alterations|323x323px]]The lung parenchyme is normal. However, the bronchus shows 6 alterations. Alteration 1, 2, 3 and 6 are PAS positive: | ||
The lung parenchyme is normal. However, the bronchus shows 6 alterations: | |||
# A mucus plug in the lumen | # A mucus plug in the lumen | ||
# Goblet cell hyperplasia in the respiratory lumen | # Goblet cell hyperplasia in the respiratory lumen | ||
| Line 14: | Line 11: | ||
# Mucus gland hyperplasia | # Mucus gland hyperplasia | ||
'''Diagnosis''': Bronchial asthma[[File:Bronchial asthma goblet cell hyperplasia.png|thumb|Goblet cell hyperplasia|325x325px]]'''Etiology''': | |||
'''Diagnosis''': Bronchial asthma | |||
'''Etiology''': | |||
* Hypersensitivity type 1 reaction | * Hypersensitivity type 1 reaction | ||
| Line 24: | Line 17: | ||
'''Theory''': | '''Theory''': | ||
The slide exists in both PAS and HE form. They’re both taken from the same preparation, at approximately the same height. | The slide exists in both PAS and HE form. They’re both taken from the same preparation, at approximately the same height. Asthma is a chronic inflammatory disorder of the airways that causes recurrent acute episodes of wheezing and cough. Intermittent and reversible airway obstruction is characteristic, along with eosinophilic inflammation of the bronchi, smooth muscle hypertrophy and hyperplasia and increased mucus production. We can recognize that we’re looking at a bronchus by the presence of cartilage. ''Recognize eosinophils for extra points on the exam.''[[File:Bronchial asthma eosinophils.png|thumb|Lymphocytes and plasma cells can also be seen, but I can’t recognize those.|274x274px|left]][[File:Bronchial asthma mucous glands.png|thumb|Mucous glands|339x339px]] | ||
Asthma is a chronic inflammatory disorder of the airways that causes recurrent acute episodes of wheezing and cough. Intermittent and reversible airway obstruction is characteristic, along with eosinophilic inflammation of the bronchi, smooth muscle hypertrophy and hyperplasia and increased mucus production. | |||
We can recognize that we’re looking at a bronchus by the presence of cartilage. | |||
''Recognize eosinophils for extra points on the exam.'' | |||
[[File:Bronchial asthma | |||
[[File:Bronchial asthma mucous glands.png | |||
[[Category:Pathology 1 - Histopathology slides]] | [[Category:Pathology 1 - Histopathology slides]] | ||
Latest revision as of 12:47, 5 July 2024
Staining: HE and PAS
Organ: Lung
Description:
The lung parenchyme is normal. However, the bronchus shows 6 alterations. Alteration 1, 2, 3 and 6 are PAS positive:
- A mucus plug in the lumen
- Goblet cell hyperplasia in the respiratory lumen
- Thickened basement membrane
- Lymphocytes, eosinophils in the sub-epithelial layer
- Smooth muscle hypertrophy and hyperplasia
- Mucus gland hyperplasia
Diagnosis: Bronchial asthma
Etiology:
- Hypersensitivity type 1 reaction
Theory:
The slide exists in both PAS and HE form. They’re both taken from the same preparation, at approximately the same height. Asthma is a chronic inflammatory disorder of the airways that causes recurrent acute episodes of wheezing and cough. Intermittent and reversible airway obstruction is characteristic, along with eosinophilic inflammation of the bronchi, smooth muscle hypertrophy and hyperplasia and increased mucus production. We can recognize that we’re looking at a bronchus by the presence of cartilage. Recognize eosinophils for extra points on the exam.
