10. Rapidly progressive GN with crescents: Difference between revisions

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[[File:RPGN - overview.png|thumb|Overview|262x262px]]'''Staining''': HE
[[File:RPGN - overview.png|thumb|Overview|224x224px]]'''Staining''': HE


'''Organ''': Kidney
'''Organ''': Kidney


'''Description''':
'''Description''':Almost all glomeruli in the slide contain some degree of fibrocellular tissue. Some glomeruli have this tissue in a half-moon-like formation called ''crescents''. The finding of crescents is associated with RPGN.


Almost all glomeruli in the slide contain some degree of fibrocellular tissue. Some glomeruli have this tissue in a half-moon-like formation called ''crescents''. The finding of crescents is associated with RPGN.
'''Diagnosis''': Rapidly progressing glomerulonephritis (RPGN)[[File:RPGN - glomerulus.png|thumb|(Mostly) normal glomerulus. The glomerular tuft occupies the whole Bowman’s space.|261x261px]]'''Causes''':
 
'''Diagnosis''': Rapidly progressing glomerulonephritis (RPGN)[[File:RPGN - glomerulus.png|thumb|(Mostly) normal glomerulus. The glomerular tuft occupies mostly the whole Bowman’s space.|261x261px]]'''Causes''':


# Goodpasture syndrome
# Goodpasture syndrome

Latest revision as of 14:34, 7 July 2024

Overview

Staining: HE

Organ: Kidney

Description:Almost all glomeruli in the slide contain some degree of fibrocellular tissue. Some glomeruli have this tissue in a half-moon-like formation called crescents. The finding of crescents is associated with RPGN.

Diagnosis: Rapidly progressing glomerulonephritis (RPGN)

(Mostly) normal glomerulus. The glomerular tuft occupies the whole Bowman’s space.

Causes:

  1. Goodpasture syndrome
  2. Immune complex mediated
    1. SLE
    2. Rheumatic fever
    3. IgA nephropathy
  3. Pauci-immune

Theory:

Crescents are formed by proliferation of parietal cells and by migration of macrophages into the Bowman’s space. They are comprised of macrophages, fibroblasts, fibrosis and possibly necrosis.

A third glomerulus

Rapidly progressing glomerulonephritis causes rapid renal failure within days. Diagnosis is based on histology.

Another glomerulus