20. DIC (fibrinthrombi in kidney) (fibrin stain): Difference between revisions

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(Created page with "'''Staining''': Weigert (fibrin) stain '''Organ''': Kidney '''Description''': Many parts of the slide are darker, but especially the glomeruli are very dark blue, sometimes black. Some tubules are also dark. '''Diagnosis''': Disseminated intravascular coagulopathy – phase 1 '''Theory''': In phase I on DIC, the thrombotic phase, will there be microthrombus and microembolism formation in every organ. In the kidney are the glomerular capillaries especially affected...")
 
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'''Staining''': Weigert (fibrin) stain
'''Staining''': Weigert (fibrin) stain[[File:DIC in kidney - overview.jpg|thumb|Overview. The small dark spots are the glomeruli, filled with fibrin.|404x404px]]'''Organ''': Kidney


'''Organ''': Kidney
'''Description''': Many parts of the slide are darker, but especially the glomeruli are very dark blue, sometimes black. Some tubules are also dark.


'''Description''':
'''Diagnosis''': DIC – phase 1


Many parts of the slide are darker, but especially the glomeruli are very dark blue, sometimes black. Some tubules are also dark.
'''Theory''': In phase I of disseminated intravascular coagulopathy (DIC), the thrombotic phase, will there be microthrombus and microembolism formation in every organ. In the kidney are the glomerular capillaries especially affected by this. Some tubules also appear to be fibrin-positive, however this is a ''false positive'' result. There is no fibrin inside the tubule cells.[[File:DIC in kidney - closer up.jpg|thumb|Closer up|left]]
 
[[File:DIC in kidney - glomeruli.jpg|thumb|The glomeruli are clearly positive for fibrin.|275x275px]]
'''Diagnosis''': Disseminated intravascular coagulopathy – phase 1
[[File:DIC in kidney - tubules.png|thumb|False positive tubules|left|262x262px]]
 
'''Theory''':
 
In phase I on DIC, the thrombotic phase, will there be microthrombus and microembolism formation in every organ. In the kidney are the glomerular capillaries especially affected by this.
 
Some tubules also appear to be fibrin-positive, however this is a ''false positive'' result. There is no fibrin inside the tubule cells.
[[File:DIC in kidney - overview.jpg|center|thumb|Overview. The small dark spots are the glomeruli, filled with fibrin.]]
[[File:DIC in kidney - closer up.jpg|center|thumb|Closer up]]
[[File:DIC in kidney - glomeruli.jpg|center|thumb|The glomeruli are clearly positive for fibrin.]]
[[File:DIC in kidney - tubules.png|center|thumb|Some tubules also appear fibrin-positive, however they don’t contain fibrin.]]
[[Category:Pathology 1 - Histopathology slides]]
[[Category:Pathology 1 - Histopathology slides]]

Latest revision as of 11:42, 5 July 2024

Staining: Weigert (fibrin) stain

Overview. The small dark spots are the glomeruli, filled with fibrin.

Organ: Kidney

Description: Many parts of the slide are darker, but especially the glomeruli are very dark blue, sometimes black. Some tubules are also dark.

Diagnosis: DIC – phase 1

Theory: In phase I of disseminated intravascular coagulopathy (DIC), the thrombotic phase, will there be microthrombus and microembolism formation in every organ. In the kidney are the glomerular capillaries especially affected by this. Some tubules also appear to be fibrin-positive, however this is a false positive result. There is no fibrin inside the tubule cells.

Closer up
The glomeruli are clearly positive for fibrin.
False positive tubules