5,045
edits
74. Macrolide antibiotics, clindamycin, chloramphenicol, oxazolidinones, streptogramins: Difference between revisions
74. Macrolide antibiotics, clindamycin, chloramphenicol, oxazolidinones, streptogramins (view source)
Revision as of 09:35, 30 April 2023
, 30 April 2023no edit summary
(Created page with "== Macrolides == === Compounds === * Erythromycin * Clarithromycin * Azithromycin === Mechanism of action === Macrolides bind to the 50S subunit of bacterial ribosomes, inhibiting translocation. This effect is bacteriostatic. === Mechanism of resistance === Resistance is often encoded by a plasmid. It can be mediated by drug efflux, enzymatic inactivation or changing the binding-site of macrolides on the ribosomes. === Pharmacokinetics === Macrolides are orally abso...") |
No edit summary |
||
| Line 63: | Line 63: | ||
=== Mechanism of action === | === Mechanism of action === | ||
It binds to the 50S ribosomal subunit, inhibiting peptide translocation. This effect is bacteriostatic. | It binds to the 50S ribosomal subunit, inhibiting peptide translocation, which in turn inhibits peptide elongation. This effect is bacteriostatic. | ||
=== Pharmacokinetics === | === Pharmacokinetics === | ||