Basal cell carcinoma: Difference between revisions

From greek.doctor
(Created page with "<section begin="dermatology" /> * Most common skin cancer * Related to mutations in the hedgehog pathway * Risk factors ** Chronic sun exposure ** Old age ** Skin types I and II * Clinical features ** Pearly papule or nodule ** Rolled border ** Central crater of ulceration ** On sun-exposed skin *** Usually upper lip/nose area ** Slow growing * Types ** Nodular BCC *** Most common type ** Superficial BCC *** On trunk *** Flat plaque lesion ** Nevoid basal cell carcinoma...")
 
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<section begin="dermatology" />
<section begin="dermatology" /><section begin="oncology" />
* Most common skin cancer
* Epidemiology
* Related to mutations in the hedgehog pathway
** Technically the most common cancer, but it is often excluded from data due to its low mortality and morbidity
** BCC accounts for 75% of all skin cancer
** Most common skin cancer
* Pathology
** Hedgehog pathway is often mutated
** Almost never metastasises, leading to low mortality and morbidity
** May cause local destruction, which may be severe if located on the face
** Types
*** Nodular BCC
*** Superficial BCC
*** Morpheaform BCC
*** Naevoid basal cell carcinoma syndrome
**** Autosomal dominant disease
**** Multiple BCC in young age
**** Bone and neurological malformations
*** +++
* Risk factors
* Risk factors
** Chronic sun exposure
** Chronic sun exposure
Line 24: Line 39:
** Locally aggressive
** Locally aggressive
* Diagnosis
* Diagnosis
** Clinical, based on typical symptoms
** Definite (histological) diagnoses often made after surgical excision of suspected lesion
** Full-thickness biopsy -> histology
** Full-thickness biopsy -> histology
* Treatment
* Treatment
** Surgical excision
** Surgery
** Irradiation
*** Surgical excision with 5 mm safety border
** Mohs micrographic surgery
*** Primary treatment is almost all cases
** Hedgehog pathway inhibitors
** Radiotherapy
** For low-risk, spf BCC
*** If surgery is not an option
** Chemotherapy
*** Only topical (5-FU)
** Alternatives for superficial and small BCCs
*** Cryosurgery
*** Photodynamic therapy
*** Photodynamic therapy
*** Cryotherapy
*** Laser ablation
*** 5-FU
*** Topical chemotherapy
*** Imiquimod cream
*** Topical imiquimod
** Targeted therapy
*** Vismodegib or sonidegib
**** Hedgehog pathway inhibitors
*** For metastatic BCC or BCC which recurs after surgery
* Follow-up
* Follow-up
** Physical examination at 3, 6, 12 months
** Physical examination at 3, 6, 12 months
** Sun protection
** Sun protection
<section end="dermatology" />
<section end="dermatology" /><section end="oncology" />
[[Category:Dermatology]]
[[Category:Dermatology]]

Latest revision as of 08:11, 14 August 2024

  • Epidemiology
    • Technically the most common cancer, but it is often excluded from data due to its low mortality and morbidity
    • BCC accounts for 75% of all skin cancer
    • Most common skin cancer
  • Pathology
    • Hedgehog pathway is often mutated
    • Almost never metastasises, leading to low mortality and morbidity
    • May cause local destruction, which may be severe if located on the face
    • Types
      • Nodular BCC
      • Superficial BCC
      • Morpheaform BCC
      • Naevoid basal cell carcinoma syndrome
        • Autosomal dominant disease
        • Multiple BCC in young age
        • Bone and neurological malformations
      • +++
  • Risk factors
    • Chronic sun exposure
    • Old age
    • Skin types I and II
  • Clinical features
    • Pearly papule or nodule
    • Rolled border
    • Central crater of ulceration
    • On sun-exposed skin
      • Usually upper lip/nose area
    • Slow growing
  • Types
    • Nodular BCC
      • Most common type
    • Superficial BCC
      • On trunk
      • Flat plaque lesion
    • Nevoid basal cell carcinoma syndrome
  • Prognosis
    • Virtually never metastasizes
    • Locally aggressive
  • Diagnosis
    • Clinical, based on typical symptoms
    • Definite (histological) diagnoses often made after surgical excision of suspected lesion
    • Full-thickness biopsy -> histology
  • Treatment
    • Surgery
      • Surgical excision with 5 mm safety border
      • Primary treatment is almost all cases
    • Radiotherapy
      • If surgery is not an option
    • Chemotherapy
      • Only topical (5-FU)
    • Alternatives for superficial and small BCCs
      • Cryosurgery
      • Photodynamic therapy
      • Laser ablation
      • Topical chemotherapy
      • Topical imiquimod
    • Targeted therapy
      • Vismodegib or sonidegib
        • Hedgehog pathway inhibitors
      • For metastatic BCC or BCC which recurs after surgery
  • Follow-up
    • Physical examination at 3, 6, 12 months
    • Sun protection