Chemotherapy: Difference between revisions
(Created page with "* Polychemotherapy = simultaneous use of multiple chemo drugs ** The term is not consistently used, even by me ** Recently, we have moved to preferring to use multiple chemo drugs, so the term is kind of reduntant * Mode of actions ** Induce DNA damage ** Inhibit DNA repair mechanisms ** Inhibit metabolism *** For example nucleotide synthesis ** Inhibit mitosis ** Inhibit neo-vascularization * Commonly used drugs ** Platinum-based drugs *** Cisplatin **** Very nephrotoxi...") |
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* Polychemotherapy = simultaneous use of multiple chemo drugs | * Polychemotherapy = simultaneous use of multiple chemo drugs | ||
** The term is not consistently used, even by me | ** The term is not consistently used, even by me | ||
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** XELOX | ** XELOX | ||
*** Capecitabine + oxaliplatin | *** Capecitabine + oxaliplatin | ||
<section end="oncology" /> | |||
[[Category:Oncology]] | [[Category:Oncology]] | ||
Latest revision as of 08:44, 27 July 2024
- Polychemotherapy = simultaneous use of multiple chemo drugs
- The term is not consistently used, even by me
- Recently, we have moved to preferring to use multiple chemo drugs, so the term is kind of reduntant
- Mode of actions
- Induce DNA damage
- Inhibit DNA repair mechanisms
- Inhibit metabolism
- For example nucleotide synthesis
- Inhibit mitosis
- Inhibit neo-vascularization
- Commonly used drugs
- Platinum-based drugs
- Cisplatin
- Very nephrotoxic – renal function must be measured before use
- Carboplatin
- Less nephrotoxic – sometimes used as an alternative to cisplatin in case of poor kidney function
- Cisplatin
- 5-Fluorouracil (FU)
- Taxanes
- Paclitaxel
- Docetaxel
- Platinum-based drugs
- Commonly used regimens
- FLOT
- 5-FU
- Leucovorin
- Oxaliplatin
- DoceTaxel
- FOLFOX
- FOLinic acid (leucovorin)
- 5-FU
- Oxaliplatin
- FOLFIRI
- FOLinic acid
- 5-FU
- IRInotecan
- ECX
- Epirubicin
- Cisplatin
- Capecitabine
- Gem/cis
- Gemcitabine + cisplatin
- XELOX
- Capecitabine + oxaliplatin
- FLOT