23. Senile plaques and neurofibrillar degeneration: Difference between revisions

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(Created page with "'''Staining''': Silver stain (Bielschowsky) '''Organ''': Brain, hippocampus '''Description''': The hippocampus is visible and that’s where the characteristic findings are visible on this slide. ''Senile plaques'' are extracellular deposits of β-amyloid that are surrounded by silver-positive proteins. The amyloids themselves aren’t stained by silver and are therefore pale. These plaques are therefore visible as large black foci with a pale core. ''Neurofibrillar...")
 
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'''Staining''': Silver stain (Bielschowsky)
[[File:Alzheimer - overview.png|thumb|Overview]]'''Staining''': Silver stain (Bielschowsky)


'''Organ''': Brain, hippocampus
'''Organ''': Brain, hippocampus


'''Description''':
'''Description''': The hippocampus is visible and that’s where the characteristic findings are visible on this slide.


The hippocampus is visible and that’s where the characteristic findings are visible on this slide.
''Senile plaques'' are extracellular deposits of β-amyloid that are surrounded by silver-positive proteins. The amyloids themselves aren’t stained by silver and are therefore pale. These plaques are therefore visible as large black foci with a pale core. ''Neurofibrillary tangles'' are intracellular bundles of hyperphosphorylated ''tau''. These tangles are stained by silver and causes the neurons to be stained black.


''Senile plaques'' are extracellular deposits of β-amyloid that are surrounded by silver-positive proteins. The amyloids themselves aren’t stained by silver and are therefore pale. These plaques are therefore visible as large black foci with a pale core.
'''Diagnosis''': Alzheimer disease (senile plaques, neurofibrillary tangles)[[File:Alzheimer - senile plaques.png|thumb|Senile plaques and amyloid cores]]'''Risk factors:'''
 
''Neurofibrillary tangles'' are intracellular bundles of hyperphosphorylated ''tau''. These tangles are stained by silver and causes the neurons to be stained black.
 
'''Diagnosis''': Alzheimer disease (senile plaques, neurofibrillary tangles)
 
'''Risk factors:'''


* Genetic factors
* Genetic factors
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* Old age
* Old age


'''Theory''':
'''Theory''': Alzheimer’s disease most commonly affects the hippocampus first, and then the frontal and temporal lobes before it becomes a diffuse process. This slide is overstained, so the characteristic findings are therefore hard to distinguish from background noise.[[File:Alzheimer - NFTs.png|thumb|These nerve cell bodies are stained black as they contain neurofibrillary tangles|left]]
 
Alzheimer’s disease most commonly affects the hippocampus first, and then the frontal and temporal lobes before it becomes a diffuse process.
 
This slide is overstained, so the characteristic findings are therefore hard to distinguish from background noise.
[[File:Alzheimer - overview.png|center|thumb|Overview]]
[[File:Alzheimer - senile plaques.png|center|thumb|Senile plaques and amyloid cores]]
[[File:Alzheimer - NFTs.png|center|thumb|These nerve cell bodies are stained black as they contain neurofibrillary tangles]]
[[Category:Pathology 2 - Histopathology slides]]
[[Category:Pathology 2 - Histopathology slides]]

Latest revision as of 14:08, 7 July 2024

Overview

Staining: Silver stain (Bielschowsky)

Organ: Brain, hippocampus

Description: The hippocampus is visible and that’s where the characteristic findings are visible on this slide.

Senile plaques are extracellular deposits of β-amyloid that are surrounded by silver-positive proteins. The amyloids themselves aren’t stained by silver and are therefore pale. These plaques are therefore visible as large black foci with a pale core. Neurofibrillary tangles are intracellular bundles of hyperphosphorylated tau. These tangles are stained by silver and causes the neurons to be stained black.

Diagnosis: Alzheimer disease (senile plaques, neurofibrillary tangles)

Senile plaques and amyloid cores

Risk factors:

  • Genetic factors
  • Down syndrome
  • Lack of physical activity
  • Traumatic brain injury
  • Old age

Theory: Alzheimer’s disease most commonly affects the hippocampus first, and then the frontal and temporal lobes before it becomes a diffuse process. This slide is overstained, so the characteristic findings are therefore hard to distinguish from background noise.

These nerve cell bodies are stained black as they contain neurofibrillary tangles