18. Diffuse large B-cell lymphoma (DLBCL): Difference between revisions

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(Created page with "'''Staining''': HE and PAS '''Organ''': Lymph node (not recognizable) '''Description''': No healthy lymph node tissue is visible. The tumor cells form no structures (like glands or nests). The cells are large and show severe atypia/pleiomorphism, almost anaplastic. The cells resemble centroblasts and are therefore said to be centroblastic in appearance or ''centroblastoid.'' There is high mitotic activity (many mitotic figures). On PAS staining are PAS-positive inclu...")
 
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'''Staining''': HE and PAS
[[File:DLBCL - overview.jpg|thumb|Overview|364x364px]]'''Staining''': HE and PAS


'''Organ''': Lymph node (not recognizable)
'''Organ''': Lymph node (not recognizable)


'''Description''':
'''Description''':[[File:DLBCL - middle magnification.png|thumb|The tumor cells form no structures. HE on the left and PAS on the right.|362x362px]]No healthy lymph node tissue is visible. The tumor cells form no structures (like glands or nests). The cells are large and show severe atypia/pleiomorphism, almost anaplastic. The cells resemble centroblasts and are therefore said to be centroblastic in appearance or ''centroblastoid.'' There is high mitotic activity (many mitotic figures).
 
No healthy lymph node tissue is visible. The tumor cells form no structures (like glands or nests). The cells are large and show severe atypia/pleiomorphism, almost anaplastic. The cells resemble centroblasts and are therefore said to be centroblastic in appearance or ''centroblastoid.'' There is high mitotic activity (many mitotic figures).


On PAS staining are PAS-positive inclusion bodies in the cytoplasm and nuclei visible, so called Russell bodies and Dutcher bodies, respectively. These inclusion bodies are comprised of immunoglobulin.
On PAS staining are PAS-positive inclusion bodies in the cytoplasm and nuclei visible, so called Russell bodies and Dutcher bodies, respectively. These inclusion bodies are comprised of immunoglobulin.


'''Diagnosis''': Diffuse large B-cell lymphoma.
'''Diagnosis''': Diffuse large B-cell lymphoma.[[File:DLBCL - high magnification.png|thumb|Look at this|383x383px]]'''Causes''':
 
'''Causes''':


* Primary type: mutations in
* Primary type: mutations in
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Necrosis is also a common histological finding in DLBCL but it can’t be seen here.
Necrosis is also a common histological finding in DLBCL but it can’t be seen here.
[[File:DLBCL - overview.jpg|center|thumb|Overview]]
[[File:DLBCL - middle magnification.png|center|thumb|The tumor cells form no structures. HE on the left and PAS on the right.]]
[[File:DLBCL - high magnification.png|center|thumb|Look at this]]
[[Category:Pathology 2 - Histopathology slides]]
[[Category:Pathology 2 - Histopathology slides]]

Latest revision as of 13:47, 7 July 2024

Overview

Staining: HE and PAS

Organ: Lymph node (not recognizable)

Description:

The tumor cells form no structures. HE on the left and PAS on the right.

No healthy lymph node tissue is visible. The tumor cells form no structures (like glands or nests). The cells are large and show severe atypia/pleiomorphism, almost anaplastic. The cells resemble centroblasts and are therefore said to be centroblastic in appearance or centroblastoid. There is high mitotic activity (many mitotic figures).

On PAS staining are PAS-positive inclusion bodies in the cytoplasm and nuclei visible, so called Russell bodies and Dutcher bodies, respectively. These inclusion bodies are comprised of immunoglobulin.

Diagnosis: Diffuse large B-cell lymphoma.

Look at this

Causes:

  • Primary type: mutations in
    • Myc
    • BCL2
    • BCL6
  • Secondary type: Richter transformation from CLL, MZL or FL

Theory:

Necrosis is also a common histological finding in DLBCL but it can’t be seen here.