11. Hyalinised glomeruli: Difference between revisions
No edit summary |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
[[File:Hyalinised glomeruli - overview.png|thumb|Overview]]'''Staining''': HE | [[File:Hyalinised glomeruli - overview.png|thumb|Overview|356x356px]]'''Staining''': HE | ||
'''Organ''': Kidney | '''Organ''': Kidney | ||
| Line 12: | Line 12: | ||
# Arteriolosclerosis of the vessels in the renal sinus | # Arteriolosclerosis of the vessels in the renal sinus | ||
'''Diagnosis''': End-stage chronic kidney disease[[File:Hyalinised glomeruli - hyalinised glomeruli vs normal.png|thumb|Hyalinised glomeruli versus healthy ones]]'''Causes''': | '''Diagnosis''': End-stage chronic kidney disease[[File:Hyalinised glomeruli - hyalinised glomeruli vs normal.png|thumb|Hyalinised glomeruli versus healthy ones|336x336px]]'''Causes''': | ||
* Diabetic nephropathy | * Diabetic nephropathy | ||
Latest revision as of 13:36, 7 July 2024
Staining: HE
Organ: Kidney
Description:
Four typical signs can be seen:
- Most glomeruli contain globular eosinophilic structures. Some glomeruli are unaffected.
- The tubulointerstitium is infiltrated by RBCs, lymphocytes and plasma cells
- The tubules contain eosinophilic substance, making they look like the thyroid histologically. This process is called thyroidisation.
- Arteriolosclerosis of the vessels in the renal sinus
Diagnosis: End-stage chronic kidney disease
Causes:
- Diabetic nephropathy
- Chronic pyelonephritis
- Rapidly progressing glomerulonephritis
- Glomerulonephritis
Theory:
Hyalinisation of the glomeruli is the morphology of the end-stage kidney disease (chronic renal failure), which is often the end-result of the conditions mentioned above.
Despite the loss of many glomeruli some are still normal and functioning, so the kidney still produces some urine.
