View source for 18. Diffuse large B-cell lymphoma (DLBCL)

[[File:DLBCL - overview.jpg|thumb|Overview|364x364px]]'''Staining''': HE and PAS

'''Organ''': Lymph node (not recognizable)

'''Description''':[[File:DLBCL - middle magnification.png|thumb|The tumor cells form no structures. HE on the left and PAS on the right.|362x362px]]No healthy lymph node tissue is visible. The tumor cells form no structures (like glands or nests). The cells are large and show severe atypia/pleiomorphism, almost anaplastic. The cells resemble centroblasts and are therefore said to be centroblastic in appearance or ''centroblastoid.'' There is high mitotic activity (many mitotic figures).

On PAS staining are PAS-positive inclusion bodies in the cytoplasm and nuclei visible, so called Russell bodies and Dutcher bodies, respectively. These inclusion bodies are comprised of immunoglobulin.

'''Diagnosis''': Diffuse large B-cell lymphoma.[[File:DLBCL - high magnification.png|thumb|Look at this|383x383px]]'''Causes''':

* Primary type: mutations in
** Myc
** BCL2
** BCL6
* Secondary type: Richter transformation from CLL, MZL or FL

'''Theory''':

Necrosis is also a common histological finding in DLBCL but it can’t be seen here.
[[Category:Pathology 2 - Histopathology slides]]