View source for 11. Hyalinised glomeruli

[[File:Hyalinised glomeruli - overview.png|thumb|Overview]]'''Staining''': HE

'''Organ''': Kidney

'''Description''':

Four typical signs can be seen:

# Most glomeruli contain globular eosinophilic structures. Some glomeruli are unaffected.
# The tubulointerstitium is infiltrated by RBCs, lymphocytes and plasma cells
# The tubules contain eosinophilic substance, making they look like the thyroid histologically. This process is called thyroidisation.
# Arteriolosclerosis of the vessels in the renal sinus

'''Diagnosis''': End-stage chronic kidney disease[[File:Hyalinised glomeruli - hyalinised glomeruli vs normal.png|thumb|Hyalinised glomeruli versus healthy ones]]'''Causes''':

* Diabetic nephropathy
* Chronic pyelonephritis
* Rapidly progressing glomerulonephritis
* Glomerulonephritis

'''Theory''':

Hyalinisation of the glomeruli is the morphology of the end-stage kidney disease (chronic renal failure), which is often the end-result of the conditions mentioned above.

Despite the loss of many glomeruli some are still normal and functioning, so the kidney still produces some urine.
[[File:Hyalinised glomeruli - wbcs.png|thumb|The WBCs here are lymphocytes and plasma cells.|left]]
[[File:Hyalinised glomeruli - thyroidisation.png|thumb|Thyroidisation. From the medulla.]]
[[File:Hyalinised glomeruli - arteriolosclerosis.png|thumb|From the sinus. Arteriolosclerosis. The affected vessel has a narrowed lumen and the vessel wall is thickened.|left]]
[[Category:Pathology 2 - Histopathology slides]]