View source for 46. Melanocytic naevus and superficially spreading melanoma

'''Staining''': HE

'''Organ''': Skin

'''Description''':

There are two pathologies here: a compound nevus and a superficial spreading melanoma.

The melanocytes that comprise nevi (called nevus cells) are morphologically different than healthy melanocytes. They have larger nuclei, no dendrites and are often found in larger numbers, while normal melanocytes are usually found alone. Nevi are characterised by the formation of nests of nevus cells. In this slide nevus cell nests are found both in the epidermis and the dermis, so the nevus is of ''compound'' type.

The superficial spreading melanoma is found to the right of the nevus. The tumor cells are atypical and have prominent eosinophilic nucleoli. Most of them contain melanin pigment.

Some melanoma cells form nests in the epidermis. Some tumor cells don’t form nests and are instead spread in the epidermis. This pattern is called ''pagetoid spread'' and is classically described as if someone shot melanoma cells at the epidermis with a shotgun.

There are nests of cells in the dermis below the melanoma as well. These cells can be nevus cells to signify that this melanoma developed from a nevus (which is rare), or they can be melanoma cells that have spread vertically downwards. They don’t look malignant, but immunohistochemistry could determine whether these cells are malignant or not with certainty.

'''Diagnosis''': Compound nevus and superficial spreading melanoma

'''Causes''':

* Sun exposure

'''Theory''':

The Breslow depth and Clarke level are used to stage melanoma.
[[File:Superficial spreading melanoma - overview.png|center|thumb|Overview]]
[[File:Superficial spreading melanoma - melanocytes.png|center|thumb|From the healthy part of the skin]]
[[File:Superficial spreading melanoma - nests.png|center|thumb|From the naevus]]
[[File:Superficial spreading melanoma - high magnification naevus.png|center|thumb|From the naevus. These are naevus cells and are morphologically different from the healthy melanocytes.]]
[[File:Superficial spreading melanoma - nests2.png|center|thumb|From the naevus]]
[[File:Superficial spreading melanoma - melanoma nests.png|center|thumb|From the melanoma]]
[[File:Superficial spreading melanoma - melanoma cells.png|center|thumb|Melanoma cells]]
[[File:Superficial spreading melanoma - nests3.png|center|thumb|From the melanoma]]
[[Category:Pathology 2 - Histopathology slides]]