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30. Phaeochromocytoma: Difference between revisions

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30. Phaeochromocytoma (view source)

Revision as of 14:17, 7 July 2024

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(Created page with "'''Staining''': HE '''Organ''': Adrenal gland '''Description''': The whole slide is tumor except for a small part on the lower right side, where we can see normal adrenal cortex. The tumor cells show mild atypia and have eosinophilic cytoplasm and produce a pattern called “zellballen”, which looks like small nests. The nests are separated by a vascular network. The cells that seperate the zellballen are called sustentacular (supporting) cells. '''Diagnosis''': P...")
 
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'''Staining''': HE
[[File:Phaeochromocytoma - overview.png|thumb|Overview]]'''Staining''': HE


'''Organ''': Adrenal gland
'''Organ''': Adrenal gland
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The tumor cells show mild atypia and have eosinophilic cytoplasm and produce a pattern called “zellballen”, which looks like small nests. The nests are separated by a vascular network. The cells that seperate the zellballen are called sustentacular (supporting) cells.
The tumor cells show mild atypia and have eosinophilic cytoplasm and produce a pattern called “zellballen”, which looks like small nests. The nests are separated by a vascular network. The cells that seperate the zellballen are called sustentacular (supporting) cells.


'''Diagnosis''': Phaeochromocytoma
'''Diagnosis''': Phaeochromocytoma[[File:Phaeochromocytoma - border.png|thumb|Border]]'''Risk factors:'''
 
'''Risk factors:'''


* Germ-line mutations in RET, NF1, VHL
* Germ-line mutations in RET, NF1, VHL
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These tumors produce catecholamines sporadically, causing paroxysmal hypertensive crises.
These tumors produce catecholamines sporadically, causing paroxysmal hypertensive crises.
[[File:Phaeochromocytoma - overview.png|center|thumb|Overview]]
[[File:Phaeochromocytoma - tumour.png|thumb|Tumour cells|left]]
[[File:Phaeochromocytoma - border.png|center|thumb|Border]]
[[File:Phaeochromocytoma - zellballs.png|thumb|Zellballen (cell balls) pattern]]
[[File:Phaeochromocytoma - tumour.png|center|thumb|Tumour cells]]
[[File:Phaeochromocytoma - zellballs.png|center|thumb|Zellballen (cell balls) pattern]]
[[Category:Pathology 2 - Histopathology slides]]
[[Category:Pathology 2 - Histopathology slides]]