16. Follicular lymphoma: Difference between revisions

'''Theory''': The translocation of the IgH gene (with its highly active promoter region) into the BCL2 (an antiapoptotic protein) on chromosome 18 causes the BCL2 gene to be overexpressed. These cells therefore have high antiapoptotic activity. Due to this is there no apoptosis in the follicles, so the “starry sky” pattern not visible.[[File:Follicular lymphoma - comparison with physiology.jpg|thumb|Left: Physiological follicular hyperplasia. Right: Follicular lymphoma. The two different slides are not at the same magnification. Note how the follicles in follicular lymphoma have less prominent and more incomplete mantle zones. Also, even at this magnification can you see the absence of “starry sky” pattern on the right picture.|left]]

[[File:Follicular lymphoma - pleomorphism.png|thumb|The tumor cells show only mild atypia/pleomorphism. This is taken from a neoplastic follicle.|left]]