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46. CMV lung: Difference between revisions

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46. CMV lung (view source)

Revision as of 12:42, 5 July 2024

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A special cell morphology called “Owl’s eye” can be seen. These cells are enlarged and have inclusion bodies inside the nucleus.
A special cell morphology called “Owl’s eye” can be seen. These cells are enlarged and have inclusion bodies inside the nucleus.


'''Diagnosis''': Cytomegalovirus pneumonitis[[File:CMV lung comparison.png|thumb|Compare the alveoli of the unaffected part of the lung (top) and the affected part (bottom). The alveoli in the unaffected lung have their characteristic wiggly shapes. The alveoli in the inflamed interstitium are round, because the interstitium has been enlarged, which has stretched the alveolar septa.|417x417px]]'''Risk factors''': Immunosuppression
'''Diagnosis''': Cytomegalovirus pneumonitis[[File:CMV lung comparison.png|thumb|Compare the alveoli of the unaffected part of the lung and the affected part. The alveoli in the unaffected lung have their characteristic wiggly shapes. The alveoli in the inflamed interstitium are round, because the interstitium has been enlarged, which has stretched the alveolar septa.|417x417px]]'''Risk factors''': Immunosuppression


'''Theory''':
'''Theory''':
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Cytomegalovirus doesn’t cause pneumonia, it causes pneumonitis, because it’s the interstitium that’s inflamed and not the alveolar space. Cells infected by the virus become very large, and accumulate inclusion bodies, which are aggregates of protein that are visible macroscopically.[[File:CMV lung alveoli.png|thumb|Yes, these are alveoli|left]]
Cytomegalovirus doesn’t cause pneumonia, it causes pneumonitis, because it’s the interstitium that’s inflamed and not the alveolar space. Cells infected by the virus become very large, and accumulate inclusion bodies, which are aggregates of protein that are visible macroscopically.[[File:CMV lung alveoli.png|thumb|Yes, these are alveoli|left]]
[[File:CMV lung owl cells.png|thumb|Owl’s eye morphology. Note the large size and the white “halo” around the nucleolus.|left]]
[[File:CMV lung owl cells.png|thumb|Owl’s eye morphology. Note the large size and the white “halo” around the nucleolus.|left]]
[[File:CMV lung owl cells 2.png|thumb|Another one. Note the inclusion bodies inside the cytoplasm]]
[[File:CMV lung owl cells 2.png|thumb|Another Owl's eye. Note the inclusion bodies inside the cytoplasm|265x265px]]
[[Category:Pathology 1 - Histopathology slides]]
[[Category:Pathology 1 - Histopathology slides]]