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34. Cervical intraepithelial neoplasia CIN III: Difference between revisions

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34. Cervical intraepithelial neoplasia CIN III (view source)

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'''Diagnosis''': Cervical intraepithelial neoplasia CIN III[[File:CIN III dysplasia transition.png|thumb|This picture shows the abrupt change from healthy, PAS-positive to PAS-negative epithelium.|264x264px]]'''Causes''': Human papilloma virus (<abbr>HPV)</abbr> infection
'''Diagnosis''': Cervical intraepithelial neoplasia CIN III[[File:CIN III dysplasia transition.png|thumb|This picture shows the abrupt change from healthy, PAS-positive to PAS-negative epithelium.|264x264px]]'''Causes''': Human papilloma virus (<abbr>HPV)</abbr> infection


'''Theory''': The normal epithelium here is the PAS-positive epithelium. The PAS positivity comes from the large amount of glycogen in the epithelial cells. Because the epithelium is stratified squamous and not columnar we know this section is from the exocervix.
'''Theory''': The normal epithelium here is the PAS-positive epithelium. The PAS positivity comes from the large amount of glycogen in the epithelial cells. Because the epithelium is stratified squamous and not columnar we know this section is from the exocervix.[[File:CIN III pleiomorphism.png|thumb|Note also that the cells are pleiomorphic.|left]]


The PAS-negative epithelium has undergone dysplasia. These cells have lost their maturation and orientation, and some undergo mitosis. The loss of maturation and orientation has caused them to not produce glycogen like healthy cells do, which makes them PAS-negative. They are also pleomorphic. They’re larger than normal epithelial cells, and don’t have the same shape as the healthy cells anymore.[[File:CIN III pleiomorphism.png|thumb|Note also that the cells are pleiomorphic.|left]]
The PAS-negative epithelium has undergone dysplasia. These cells have lost their maturation and orientation, and some undergo mitosis. The loss of maturation and orientation has caused them to not produce glycogen like healthy cells do, which makes them PAS-negative. They are also pleomorphic. They’re larger than normal epithelial cells, and don’t have the same shape as the healthy cells anymore.


The cells with the perinuclear halo and irregular nuclei are called koilocytes, which are a sign of HPV infection. The presence of these cells is called koilocytosis or koilocytic atypia.
The cells with the perinuclear halo and irregular nuclei are called koilocytes, which are a sign of HPV infection. The presence of these cells is called koilocytosis or koilocytic atypia.