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58. Silicosis: Difference between revisions

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58. Silicosis (view source)

Revision as of 11:40, 5 July 2024

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'''Organ''': Lung + lymph nodes
[[File:Silicosis prep front.jpg|thumb|Silicosis prep front]]'''Organ''': Lung + lymph nodes


'''Description''':
'''Description''':
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* Occupational disease, silica dust inhalation
* Occupational disease, silica dust inhalation


'''Theory''':[[File:Silicosis prep front.jpg|thumb|Silicosis prep front]]Several occupations are associated with exposure to silica dust, like miners and stone cutters. When these people inhale the dust, it will be eaten by alveolar macrophages. However, because the silica dust is inorganic can’t the macrophages break it down. The macrophages respond by producing cytokines that recruit fibroblasts. Progressive fibrosis occurs.
'''Theory''':
 
Several occupations are associated with exposure to silica dust, like miners and stone cutters. When these people inhale the dust, it will be eaten by alveolar macrophages. However, because the silica dust is inorganic can’t the macrophages break it down. The macrophages respond by producing cytokines that recruit fibroblasts. Progressive fibrosis occurs.


In this preparation are silicotic nodules not ''macroscopically'' visible in the lung parenchyme, however histology of the lung would definitely show those nodules. However, we can see silicotic nodules as greyish dots inside the hilar and mediastinal lymph nodes.
In this preparation are silicotic nodules not ''macroscopically'' visible in the lung parenchyme, however histology of the lung would definitely show those nodules. However, we can see silicotic nodules as greyish dots inside the hilar and mediastinal lymph nodes.