Nikolas
Created page with "'''Sickle cell disease''' is a group of inherited RBC disorders, and the most common intrinsic haemolytic anaemia, i.e. the most common cause of haemolytic anaemia due to intrinsic defects of the RBCs. It’s most common in African and Mediterranean populations. It’s caused by a point mutation in the beta globin gene causes haemoglobin to precipitate into a sickle-shape when deoxygenized, which gives the name. This leads to microvascular occlusion and haemolysis...."