Small bowel cancer is very rare, accounting for <5% of GI cancers. Most small bowel tumours are benign. Cancer may be adenocarcinoma, neuroendocrine, lymphoma, GIST, or other mesenchymal cancers.

Gastrointestinal stromal tumour (GIST) is a mesenchymal tumour of the GI tract. It may occur anywhere in the GI-tract, but most frequently in the stomach and small intestine.