Monoclonal gammopathy

Monoclonal gammopathy refers to any condition where there is excessive amounts of a monoclonal gammaglobulin in the blood, as evidenced by the presence of a tall peak in the gamma band on serum electrophoresis. These monoclonal gammaglobulins are called "M proteins". Monoclonal gammopathy is the opposite of polyclonal gammopathy.

The following are the most common monoclonal gammopathies:

• Monoclonal gammopathy of unknown significance (most common)
• Multiple myeloma
• Waldenström macroglobulinaemia
• Light chain amyloidosis