- Caused by HHV8, immunosuppression is risk factor
- Malignant tumor of endothelial cells
- 4 types
- Classic – in older males
- Endemic – in Africa
- Immunosuppressive therapy-related
- AIDS-related
- Clinical features
- Multiple cutaneous lesions
- Purplish macules -> patches -> papules -> plaques -> nodules
- Rapidly growing
- Initially seen on face, oral cavity or chest
- Organs can be involved
- Treatment
- Classic KS -> surgery or radiotherapy
- HIV-related KS -> treatment of AIDS alone may cause cancer regression
- KS associated with non-HIV immunosuppression -> changing immunosuppressing drug alone may cause regression