Ewing sarcoma

• Epidemiology
  • Children, adolescents
  • Boys > girls
• Clinical features
  • Can occur in any bone
    • Most often in diaphysis of long bones
  • Highly malignant
  • Night pain
  • B symptoms
• Diagnosis
  • Resembles osteomyelitis on x-ray, MRI and histology
  • Immunohistological staining or PCR helps to differentiate
• Treatment
  • Neoadjuvant polychemo + limb-sparing surgery + adjuvant polychemo
  • Radiation may also be used