Cutaneous T-cell lymphomas

• Mycosis fungoides
  • CD4+ T-cell lymphoma
  • Progresses slowly
  • Stage I – patch stage
    • Scaly, pruritic, well-demarcated patches
  • Stage II – plaque stage
    • Scaly, pruritic, well-demarcated plaques
    • Large
  • Stage III – tumor stage
    • Dome-shaped purple or red nodules
  • Treatment
    • Topical steroids
    • Topical chemo
    • Phototherapy
    • Biological therapy
    • Systemic chemo
• Sézary syndrome
  • Can develop from mycosis fungoides or de novo
  • Clinical triad
    • Systemic skin lesions
      • Erythroderma
      • Palmar and plantar hyperkeratosis
      • Pruritus
    • Generalized lymphadenopathy
    • Atypical T-cells in blood
  • Treatment
    • Extracorporal photopheresis
    • Phototherapy
    • Chemotherapy
• Adult cutaneous T-cell leukaemia/lymphoma
  • HTLV-I associated
  • Similar lesions to mycosis fungoides