59. Paget’s disease

Organ: Breast

Description:

The nipple is firm, inflamed and hyperkeratotic.

Diagnosis: Paget disease of the breast

Causes:

DCIS or invasive carcinoma

Theory:

Paget disease of the breast is a manifestation of DCIS or invasive breast carcinoma where the nipple becomes inflamed and hyperkeratotic as tumor cells invade the skin of the nipple.