49. Giant cell tumor of bone (osteoclastoma)
Staining: HE
Organ: Bone tumor sampled by curettage
Description:
The purplish things are pieces of the tumor. The pinkish things are not.
The tumor pieces are comprised of two types of cell. There are osteoclast-type giant cells, which have large eosinophilic cytoplasm and many nuclei. These cells are not neoplastic; they are reactive cells.
The cells that are between the giant cells are the neoplastic cells. These cells are primitive mesenchymal cells with poorly defined cytoplasm.
Diagnosis: Giant cell tumor of bone
Risk factors:
- Age 20 – 45
Theory:
The old name for this tumor is “osteoclastoma”.
