15. Toxoplasma lymphadenitis

Staining: HE

Overview

Organ: Lymph node

Description:

There is extreme(ly large) follicular hyperplasia, as seen by the abnormally large germinal centres. With higher magnification are small granulomas visible, so-called microgranulomas. In a small, triangular area on the right part of the slide can we see B-cells that resemble monocytes, so-called monocytoid B-cell hyperplasia.

Diagnosis: Toxoplasma lymphadenitis

Causes: Toxoplasmosis

Theory:

Toxoplasmosis is a condition caused by infection by the parasite toxoplasma gondii. In 90% of cases is the condition asymptomatic. Especially those that are immunocompromised are at risk to develop symptoms, which includes lymphadenitis. It’s part of TORCH.

Microgranulomas

Monocytoid B-cell hyperplasia. From the triangular area on the right part of the slide.