12. Kimmelstiel Wilson syndrome

Staining: PAS-H

Overview

Organ: Kidney

Description:

Even with low magnification are PAS-positive glomeruli visible. With higher magnification are PAS-positive nodules inside the glomeruli visible.

Diagnosis: Nodular glomerulosclerosis

Causes:

• Diabetes

Theory:

Nodules

Nodular glomerulosclerosis is the third and last stage of diabetic nephropathy. It occurs as a result of glucose combining with proteins in the glomerular vessel wall to form AGE products. AGEs stimulate the mesangial cells to produce more mesangial matrix, which is what forms the PAS positive nodules. The nodules are called Kiemmelstiel-Wilson nodules or lesions.