Kaposi sarcoma

• Caused by HHV8, immunosuppression is risk factor
• Malignant tumor of endothelial cells
• 4 types
  • Classic – in older males
  • Endemic – in Africa
  • Immunosuppressive therapy-related
  • AIDS-related
• Clinical features
  • Multiple cutaneous lesions
    • Purplish macules -> patches -> papules -> plaques -> nodules
  • Rapidly growing
  • Initially seen on face, oral cavity or chest
  • Organs can be involved
• Treatment
  • Classic KS -> surgery or radiotherapy
  • HIV-related KS -> treatment of AIDS alone may cause cancer regression
  • KS associated with non-HIV immunosuppression -> changing immunosuppressing drug alone may cause regression