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Bullous pemphigoid

Revision as of 16:51, 17 July 2024 by Nikolas (talk | contribs) (Created page with "<section begin="dermatology" />* In elderly * Benign disease, responds well to treatment * Most common autoimmune bullous disease * Pathomechanism ** Autoantibodies against hemidesmosomes * Clinical features ** Prodromal stage *** Weeks before onset of blistering *** Urticarial lesions ** Large, tense, subepidermal bulla *** Don’t rupture easily ** Intensely pruritic ** Lower limbs, axilla ** Rarely oral involvement * Diagnosis ** Negative Nikolsky ** Histology and imm...")
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  • In elderly
  • Benign disease, responds well to treatment
  • Most common autoimmune bullous disease
  • Pathomechanism
    • Autoantibodies against hemidesmosomes
  • Clinical features
    • Prodromal stage
      • Weeks before onset of blistering
      • Urticarial lesions
    • Large, tense, subepidermal bulla
      • Don’t rupture easily
    • Intensely pruritic
    • Lower limbs, axilla
    • Rarely oral involvement
  • Diagnosis
    • Negative Nikolsky
    • Histology and immunofluorescence
  • Treatment
    • Prednisone (0,5 – 1 mg/bwkg)
    • Azathioprine, immunosuppressants