Herpes simplex virus infection
This article is a stub, meaning that it is unfinished. It will eventually be expanded.
- Herpes viruses
- α herpes viruses
- Lie latent in sensory ganglia neurons
- Replicate quickly
- Herpes simplex 1
- Herpes simplex 2
- Varicella zoster virus
- β herpes viruses
- Lie latent in leukocytes
- Human herpes virus 6 – roseola infantum/sixth disease
- Human herpes virus 7
- CMV
- γ herpes viruses
- Lie latent in lymphocytes
- Human herpes virus 8
- EBV
- Are oncogenic
- α herpes viruses
- HSV infections
- Labial herpes
- On lips
- HSV-1 in 90%
- HSV-2 in 10%
- Clinical features
- Prodromal symptoms – 24 hours before outbreak
- Pain
- tingling
- Burning
- Recurring, erythematous vesicles that turn into painful ulcerations
- Prodromal symptoms – 24 hours before outbreak
- Complications
- Herpetic gingivostomatitis
- In children and immunocompromised
- Often the primary infection
- Erythema, painful ulceration on perioral skin and oral mucosa
- Herpetic gingivostomatitis
- Genital herpes
- On genital organs
- HSV-2 in most cases
- HSV-1 rarely
- Incubation period – 2 – 7 days
- Clinical features
- Many are asymptomatic
- Painful lymphadenopathy
- Vesicles that ulcerate
- Eczema herpeticum
- HSV-1, HSV-2
- On pre-existing skin conditions
- Atopic dermatitis
- Extensive disseminated and painful eruptions on head and upper body
- Erythematous skin with multiple, round vesicles
- It’s an emergency
- Treatment -> IV acyclovir
- Herpetic whitlow
- In children and healthcare workers who come into contact with saliva
- Direct contact with infected saliva through a break in the skin
- Pain, burning, oedema in finger
- Lymphadenopathy
- Treatment
- Decreases duration and severity
- Most effective if initiated within 72 hours
- Mild disease
- Oral acyclovir (5 x 800mg for 10 days)
- Severe disease
- IV acyclovir
- Acyclovir-resistance -> foscarnet
- Labial herpes