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Squamous cell carcinoma of the skin

Revision as of 11:44, 18 June 2024 by Nikolas (talk | contribs) (Created page with "<section begin="dermatology" /> * Second most common skin cancer * Risk factors ** Chronic sun exposure ** Precancerous lesions *** Actinic keratosis *** Bowen disease (SCC in situ) *** Leukoplakia ** Radiation ** Chronic scars, ulcers ** Arsenic, tar * Clinical features ** Painless, non-healing, bleeding ulcer or nodule ** Rapid growing ** On sun-exposed areas *** Face and neck *** Lower lip * Prognosis ** 5% risk of metastasis * Diagnosis ** Punch biopsy * Treatment **...")
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  • Second most common skin cancer
  • Risk factors
    • Chronic sun exposure
    • Precancerous lesions
      • Actinic keratosis
      • Bowen disease (SCC in situ)
      • Leukoplakia
    • Radiation
    • Chronic scars, ulcers
    • Arsenic, tar
  • Clinical features
    • Painless, non-healing, bleeding ulcer or nodule
    • Rapid growing
    • On sun-exposed areas
      • Face and neck
      • Lower lip
  • Prognosis
    • 5% risk of metastasis
  • Diagnosis
    • Punch biopsy
  • Treatment
    • Surgical excision with 5 mm safety border
    • Radiation therapy
    • Mohs micrographic surgery
    • For low-risk, small
      • Cryotherapy
      • Curettage
    • For metastasis
      • Chemotherapy
        • Platina
        • 5-FU
      • EGFR inhibitors – cetuximab
      • PD-1 inhibitor – cemeplimab
  • Follow-up
    • Physical examination
    • Regional ultrasound
    • Chest x-ray
    • Abdominal US
    • Sun protection