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Basal cell carcinoma

Revision as of 12:44, 18 June 2024 by Nikolas (talk | contribs) (Created page with "<section begin="dermatology" /> * Most common skin cancer * Related to mutations in the hedgehog pathway * Risk factors ** Chronic sun exposure ** Old age ** Skin types I and II * Clinical features ** Pearly papule or nodule ** Rolled border ** Central crater of ulceration ** On sun-exposed skin *** Usually upper lip/nose area ** Slow growing * Types ** Nodular BCC *** Most common type ** Superficial BCC *** On trunk *** Flat plaque lesion ** Nevoid basal cell carcinoma...")
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  • Most common skin cancer
  • Related to mutations in the hedgehog pathway
  • Risk factors
    • Chronic sun exposure
    • Old age
    • Skin types I and II
  • Clinical features
    • Pearly papule or nodule
    • Rolled border
    • Central crater of ulceration
    • On sun-exposed skin
      • Usually upper lip/nose area
    • Slow growing
  • Types
    • Nodular BCC
      • Most common type
    • Superficial BCC
      • On trunk
      • Flat plaque lesion
    • Nevoid basal cell carcinoma syndrome
  • Prognosis
    • Virtually never metastasizes
    • Locally aggressive
  • Diagnosis
    • Full-thickness biopsy -> histology
  • Treatment
    • Surgical excision
    • Irradiation
    • Mohs micrographic surgery
    • Hedgehog pathway inhibitors
    • For low-risk, spf BCC
      • Photodynamic therapy
      • Cryotherapy
      • 5-FU
      • Imiquimod cream
  • Follow-up
    • Physical examination at 3, 6, 12 months
    • Sun protection