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Burkitt lymphoma

Revision as of 09:50, 23 October 2023 by Nikolas (Sọ̀rọ̀ | contribs) (Created page with "'''Burkitt lymphoma''' (BL) is an aggressive non-Hodgkin lymphoma. It's infamous for being one of the most rapidly growing tumours, with a doubling time less than 24 hours. It’s characterised by deregulation of c-Myc. Three forms of Burkitt lymphoma can be distinguished: * Sporadic Burkitt lymphoma * Endemic Burkitt lymphoma * HIV-associated Burkitt lymphoma Endemic BL is endemic to equat...")
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Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma. It's infamous for being one of the most rapidly growing tumours, with a doubling time less than 24 hours. It’s characterised by deregulation of c-Myc. Three forms of Burkitt lymphoma can be distinguished:

  • Sporadic Burkitt lymphoma
  • Endemic Burkitt lymphoma
  • HIV-associated Burkitt lymphoma

Endemic BL is endemic to equatorial Africa and South America and is highly associated with EBV infection. Non-endemic BL presents as a mass in the abdomen, while endemic BL presents as a mass in the jaw.

Because it’s so rapidly proliferating, BL must be managed as acute leukaemia. There is significant risk of tumour lysis syndrome.

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