Marginal zone lymphoma

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Marginal zone lymphoma (MZL) is an indolent non-Hodgkin lymphoma can be extranodal, nodal, or splenic, where the former is most common. Extranodal MZL originates from MALT and is associated with chronic inflammation or infection, for example in case of:

  • H. pylori infection – gastric MALT lymphoma
  • Chlamydia psittaci infection in the eye – ocular adnexal lymphoma
  • Sjögren syndrome – MALT lymphoma in the salivary glands

Treating the underlying infection or inflammation often causes the malignancy to enter complete remission.