Cytokines

The cytokines and effects which are bolded are the most important.

Cytokine	Produced by which cell?	Effects
IL-1	Macrophages	Inflammatory, acute phase reaction
IL-2	Th1	Induce T-cell proliferation, activate CTL cells, induce Th ⇒ Treg,
IL-3	Th2	Myeloid lineage stimulator
IL-4	Th2, mast cells, NK cells, dendritic cells	Anti-inflammatory. Activate mast cells, induce isotype switch to IgG1 and IgE, Induce Th ⇒ Th2
IL-5	Th2	Activate eosinophils
IL-6	Macrophages	Inflammatory, acute phase reaction. Induce Th ⇒ T17
IL-7		Survival of B-cells in periphery, proliferation of T-cells in thymus, lymphoid lineage stimulator.
IL-10	APCs, Treg	Anti-inflammatory, inhibit effector cells, activate Treg
IL-12	Macrophages, dendritic cells	Induce Th ⇒ Th1
IL-13	Th2	Induce isotype switch to IgE
IL-17	Th17	Inflammatory
IL-35	APCs, Treg	Anti-inflammatory, inhibit effector cells, activate Treg
TNF-α	Th1	Inflammatory
TGF-β	APCs, Treg	Anti-inflammatory, inhibit effector cells, activate Treg, induce isotype switch to IgA
IFN-γ	Macrophages, Th1	Inflammatory, acute phase reaction, induce isotype switch to IgG1
SCF		Stem cell proliferation