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  • 10:56, 1 March 2023 Nikolas talk contribs created page 44. Etiology and pathogenesis of 2DM (Created page with "== Etiology == Genetic factors: The concordance between identical twins is around 80%, indicating a much stronger genetic factor than for 1DM. The specific genetic factors involved are not as well known as for 1DM, but it’s certain that HLA plays no role. Possible genes that are mutated in 2DM include: * GLUT2 * PPAR-γ * GLUT4 * GCGR – the glucagon receptor gene * TCF7L2 – a transcription factor that is active in β-cells – the most significant gene associated...") Tag: Visual edit