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  • 10:55, 1 March 2023 Nikolas talk contribs created page 43. Etiology and pathogenesis of 1DM (Created page with "== Etiology == The basic mechanism behind 1DM is a destruction of pancreatic β-cells. The other endocrine functions of the pancreas are usually maintained. The exact cause of the destruction isn’t completely understood. There are both genetic and environmental factors. Genetic factors: Concordance between identical twins is only 40% and between parent and child only 5%. This indicates that genetic factors play only a minor role. Certain types of HLA, especially HLA-D...") Tag: Visual edit