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- 13:09, 10 January 2023 Nikolas talk contribs created page 12. Urea cycle and ammonium metabolism (Created page with "== Learning objectives == * Why must ammonium be excreted? * How is ammonium excreted in humans? * What are the sources of ammonium? * Describe the urea cycle * Which is the rate-limiting step of the urea cycle? * How is the urea cycle regulated? * What is the aspartate-argininosuccinate shunt? == Excretion of ammonium == Ammonium is toxic, especially to the brain, and so it should be excreted. In humans ammonium is excreted in the form of urea. Urea is water-soluble a...") Tag: Visual edit