9. Hepatocellular carcinoma in cirrhosis: Difference between revisions
(Created page with "'''Staining''': HE '''Organ''': Liver '''Description''': There is no healthy liver parenchyme visible. On the left part of the slides can we see some pseudolobules of varying size and without central veins. On the rest of the slide can we see large nodules with cells that show pleiomorphism, atypia and mitotic activity. Some of the tumor cells show intranuclear inclusion bodies. Coagulative necrosis is also visible in the in the upper right corner inside the right l...") |
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Revision as of 09:50, 16 June 2022
Staining: HE
Organ: Liver
Description:
There is no healthy liver parenchyme visible.
On the left part of the slides can we see some pseudolobules of varying size and without central veins.
On the rest of the slide can we see large nodules with cells that show pleiomorphism, atypia and mitotic activity. Some of the tumor cells show intranuclear inclusion bodies. Coagulative necrosis is also visible in the in the upper right corner inside the right large nodule.
Diagnosis: Hepatocellular carcinoma (HCC)
Causes:
- Alcoholic/viral/metabolic hepatitis -> cirrhosis -> HCC
Theory:
The pseudolobules indicate that there is cirrhosis present. The larger nodules with atypia and necrosis are nodules of the hepatocellular carcinoma.
Almost all cases of hepatocellular carcinoma develop in cirrhotic livers. The only exception is the fibrolamellar type of HCC.
