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Sepsis: Difference between revisions
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<section begin="A&IC" /><section begin="pathophysiology" /><section begin="clinical biochemistry" />'''Sepsis''' is an acute life-threatening condition characterised by organ dysfunction caused by a dysregulated host response to infection, usually bacterial. It’s related to [[systemic inflammatory response syndrome]] (SIRS) in pathomechanism. It has a very high mortality rate and can lead to [[multiple organ dysfunction syndrome]] (MODS) and death.<section end="clinical biochemistry" /> | <section begin="pathophys1" /><section begin="A&IC" /><section begin="pathophysiology" /><section begin="clinical biochemistry" />'''Sepsis''' is an acute life-threatening condition characterised by organ dysfunction caused by a dysregulated host response to infection, usually bacterial. It’s related to [[systemic inflammatory response syndrome]] (SIRS) in pathomechanism. It has a very high mortality rate and can lead to [[multiple organ dysfunction syndrome]] (MODS) and death.<section end="clinical biochemistry" /> | ||
'''Septic shock''' is defined as “A subset of sepsis in which underlying circulatory and cellular or metabolic abnormalities lead to substantially increased mortality risk.” As the name implies it implies the state where a person has sepsis and circulatory shock, often of the distributive type. A person is said to be in septic shock if: | '''Septic shock''' is defined as “A subset of sepsis in which underlying circulatory and cellular or metabolic abnormalities lead to substantially increased mortality risk.” As the name implies it implies the state where a person has sepsis and circulatory shock, often of the distributive type. A person is said to be in septic shock if: | ||
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* Lactate – which is proportional to the degree of tissue hypoxia | * Lactate – which is proportional to the degree of tissue hypoxia | ||
* Thrombocytes - thrombocytopaenia is common | * Thrombocytes - thrombocytopaenia is common | ||
<section end="clinical biochemistry" /> | <section end="clinical biochemistry" /><section end="pathophys1" /> | ||
== Treatment == | == Treatment == | ||
Management according to the 2016 surviving sepsis campaign (SSC). The therapeutic goals are: | Management according to the 2016 surviving sepsis campaign (SSC). The therapeutic goals are: | ||