Metabolic alkalosis: Difference between revisions

Metabolic alkalosis (view source)

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 == Pathophysiology ==
-The healthy kidney can compensate for metabolic alkalosis by increasing its excretion of bicarbonate quickly and to a large degree. As such, for metabolic alkalaemia to occur, there is often a loss of kidney function.
+Alkalaemia may cause plasma proteins to bind more free calcium ions, causing the level of free calcium in the serum to decrease, effectively causing hypocalcaemia.
+Alkalaemia also shifts the haemoglobin-oxygen dissociation curve to the left, which decreases tissue oxygenation.
+=== Compensation ===
+The initial compensation occurs to intracellular buffers like the haemoglobin buffers, and is relatively modest.
+The healthy kidney can compensate for metabolic alkalosis by increasing its excretion of bicarbonate to a large degree. As such, for metabolic alkalaemia to occur, there is often a loss of kidney function. Renal compensation begins soon after the alkalosis, but it takes up to five takes to become complete.
 == Clinical features ==