Nikolas
Created page with "'''Primary myelofibrosis''' (PMF), previously known as '''osteomyelofibrosis''', is a myeloproliferative neoplasm characterised by proliferation of granulocyte and megakaryocyte lineages, as well as eventual deposition of fibrous connective tissue in the bone marrow. PMF has two phases. In the prefibrotic phase, the bone marrow is hypercellular, while in the fibrotic phase, the bone marrow undergoes fibrosis. 50% of PMF cases are associated with JAK2 mutation. The..."