Nikolas
Created page with "<section begin="dermatology" />* In elderly * Benign disease, responds well to treatment * Most common autoimmune bullous disease * Pathomechanism ** Autoantibodies against hemidesmosomes * Clinical features ** Prodromal stage *** Weeks before onset of blistering *** Urticarial lesions ** Large, tense, subepidermal bulla *** Don’t rupture easily ** Intensely pruritic ** Lower limbs, axilla ** Rarely oral involvement * Diagnosis ** Negative Nikolsky ** Histology and imm..."